Developing and managing hundreds (or maybe thousands) of microservices at scale is a challenge for both development and operations teams. We have seen over the last few years the appearance of new frameworks dedicated to deliver Cloud Native applications by providing a set of (out of box) building blocks. Most of these frameworks integrate microservices concerns at the code level. Recently, we have seen the emergence of a new pattern known as sidecar or proxy promoting to push all these common concerns outside of the business code and provides them on the edge by integrating a new layer to the underlying platform called Service Mesh. Istio is one of the leading Service Mesh implementing sidecar pattern. We will go during the presentation throw the core concepts behind Istio, the capabilities that provides to manage, secure and observe microservices and how it gives a new breath for both developers and operations.